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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2A
All Species:
17.58
Human Site:
T512
Identified Species:
29.74
UniProt:
Q9BY44
Number Species:
13
Phosphosite Substitution
Charge Score:
0.38
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BY44
NP_114414.2
585
64990
T512
K
S
P
D
L
A
P
T
P
A
P
Q
S
T
P
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001108004
580
64436
T507
K
S
P
D
L
A
P
T
P
A
P
Q
S
T
P
Dog
Lupus familis
XP_534306
585
65159
T512
K
S
P
D
L
A
P
T
P
A
P
Q
S
T
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8BJW6
581
64385
T508
A
R
S
D
A
A
P
T
P
V
P
Q
S
A
P
Rat
Rattus norvegicus
NP_001102809
541
60196
E488
Q
S
A
S
G
D
P
E
V
D
K
K
I
K
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507598
493
54394
E440
L
P
T
S
G
D
P
E
V
D
K
K
I
K
N
Chicken
Gallus gallus
Q5ZKC1
586
64485
S513
C
S
Q
E
S
T
Q
S
S
A
S
Q
N
T
P
Frog
Xenopus laevis
Q7ZY11
582
64798
T513
E
P
A
E
S
D
S
T
N
V
Q
N
N
T
P
Zebra Danio
Brachydanio rerio
Q4QRJ7
580
64206
D512
E
A
P
P
P
A
A
D
P
A
P
V
S
H
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VNX8
638
70052
D563
P
R
Q
K
Y
Q
P
D
N
A
A
D
Q
P
P
Honey Bee
Apis mellifera
XP_625143
577
65273
S509
T
N
G
Q
V
T
T
S
T
E
T
Q
N
L
T
Nematode Worm
Caenorhab. elegans
Q19052
570
64001
P512
G
N
G
N
A
P
Q
P
F
R
P
Q
Q
S
E
Sea Urchin
Strong. purpuratus
XP_001186352
299
33040
C245
Q
H
Y
A
T
A
I
C
A
P
R
L
R
V
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53235
642
71286
D566
K
S
S
E
T
S
P
D
S
T
P
A
P
S
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.4
96
N.A.
92.8
82.5
N.A.
74.5
84.4
74.8
69.5
N.A.
39
43.9
35.7
29.2
Protein Similarity:
100
N.A.
98.2
98.2
N.A.
95.5
87
N.A.
79.4
91.6
86.5
81.5
N.A.
56.5
61.3
54.8
40
P-Site Identity:
100
N.A.
100
100
N.A.
60
13.3
N.A.
6.6
33.3
20
40
N.A.
20
6.6
13.3
6.6
P-Site Similarity:
100
N.A.
100
100
N.A.
60
26.6
N.A.
13.3
53.3
40
53.3
N.A.
20
33.3
33.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
15
8
15
43
8
0
8
43
8
8
0
8
8
% A
% Cys:
8
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
29
0
22
0
22
0
15
0
8
0
0
0
% D
% Glu:
15
0
0
22
0
0
0
15
0
8
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
8
0
15
0
15
0
0
0
0
0
0
0
0
0
8
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
0
0
0
0
8
0
0
0
0
0
15
0
0
% I
% Lys:
29
0
0
8
0
0
0
0
0
0
15
15
0
15
0
% K
% Leu:
8
0
0
0
22
0
0
0
0
0
0
8
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
15
0
8
0
0
0
0
15
0
0
8
22
0
15
% N
% Pro:
8
15
29
8
8
8
58
8
36
8
50
0
8
8
50
% P
% Gln:
15
0
15
8
0
8
15
0
0
0
8
50
15
0
0
% Q
% Arg:
0
15
0
0
0
0
0
0
0
8
8
0
8
0
0
% R
% Ser:
0
43
15
15
15
8
8
15
15
0
8
0
36
15
0
% S
% Thr:
8
0
8
0
15
15
8
36
8
8
8
0
0
36
8
% T
% Val:
0
0
0
0
8
0
0
0
15
15
0
8
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
8
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _